Holders Barcelona will face fellow Spaniards Atletico Madrid, runners-up two seasons ago, in the Champions League quarter-finals following the draw in Nyon on Friday.
Atletico Madrid surrendered top spot in La Liga to Barcelona when they were held to a 0-0 draw at home to 10-man Sevilla in a fiercely contested La Liga clash on Sunday.
An insatiable Lionel Messi scored for the eighth game in a row in all competitions as La Liga champions Barcelona saw off a gutsy Girona side 2-0 to go five points clear at the top of the standings.
A summary of Thursday night's UEFA Champions League matches.
News of all that's transpired on and off the football field
Images from the UEFA Champions League quarter-final first leg matches played on Wednesday
Atletico Madrid captain Gabi said his team would not be lulled into complacency by Barcelona's faltering form when they host the Champions League holders in the second leg of their quarter-final on Wednesday.
Images from the Champions League matches played across Europe on Tuesday
Fernando Torres stole the show with a dramatic double as Atletico Madrid secured a battling 2-2 draw at Real Madrid on Thursday that dumped the holders out of the King's Cup 4-2 on aggregate.
Images from the football matches played on Tuesday.
Real Madrid's Javier Hernandez struck twice as they came from behind to beat Celta Vigo 4-2 away and keep the pressure on Barcelona at the top of La Liga on Sunday.
A summary of the opening day's action in the UEFA Champions league on Tuesday.
Sevilla joined holders Real Madrid in the last 16 of the King's Cup when a quick-fire Iago Aspas hat-trick helped secure a crushing 11-2 aggregate victory over second-division Sabadell on Wednesday.
Arsenal will have another chance to beat Bayern Munich in a Champions League knockout tie after the sides were paired in the round of 16 following Monday's draw. The teams met in the knockout stages in 2005, 2013 and 2014 with the German champions winning on all three occasions. Bayern, who finished as runners-up in their group, will host the first leg.
Two goals by Alexis Sanchez -- his first in the Champions League -- led Barcelona to a 3-1 first-leg win at Bayer Leverkusen on Tuesday to put the holders in the driving seat in their round of 16 tie.
Manchester City's Erling Haaland faces Borussia Dortmund and Barcelona's Robert Lewandowski meets Bayern Munich after the Champions League group-stage draw was made on Thursday.
Shakhtar Donetsk led the way for the Champions League underdogs as they beat holders Chelsea 2-1 while former European champions Barcelona and Manchester United came from behind to maintain perfect starts on Tuesday.
Barcelona, AC Milan and Arsenal can all book places in the knockout stages of the Champions League with wins on Tuesday.
Luis Fabiano scored twice for Sevilla as the 2007 King's Cup winners eased into the quarter-finals with a 3-0 victory at Deportivo Coruna in their second leg tie on Wednesday.
Atletico Madrid tamed Lionel Messi and Neymar to send La Liga rivals Barcelona crashing out of the Champions League after Koke's early goal secured a shock 2-1 aggregate success at the Calderon on Wednesday.
Lionel Messi fired Barcelona into the last 16 of the Champions League with two goals in their 3-0 victory at Spartak Moscow on Tuesday but holders Chelsea are walking a tightrope after a crushing defeat by Juventus.
Images from the Champions League matches plsyed across Europe on Wednesday.
A round-up of Wednesday's action in the UEFA Champions League
Chelsea nervously beat Benfica 2-1 in their Champions League quarter-final second leg at Stamford Bridge on Wednesday to seal a 3-1 aggregate victory and set up a semi-final with holders Barcelona later this month. Real Madrid completed an 8-2 aggregate, thrashing of APOEL Nicosia, in the night's other match.
The old format was skewed in favour of the bigger clubs, who could rest players for a first leg and swallow defeat before calling on their stars to turn the tie around in the return game.
Holders Barcelona booked a Champions League last 16 berth with a 2-1 win at Dynamo Kiev on Wednesday and were joined by Group F rivals Inter Milan, who sealed their passage with a 2-0 home defeat of Rubin Kazan.
Holders Barcelona will play Bayer Leverkusen, a team famous for fading in the final straight, while their arch-rivals Real Madrid face a trip to icy Moscow in the Champions League round of 16 following the draw on Friday. Bayern Munich, whose Allianz Arena will host the final, take on FC Basel, the underdogs who spectacularly ousted Manchester United, in another of the top ties.
Barcelona defender Gerard Pique will miss this week's European Super Cup clash with Porto due to a calf injury, the Champions League holders said on Tuesday.
The chinks in Inter Milan's armour were exposed again as Tottenham Hotspur beat the holders 3-1 in Champions League Group A and all three teams able to secure last-16 qualification flopped on Tuesday.
Written off as too old and accused of hastening the downfall of Andre Villas-Boas, Chelsea's old guard have flourished under stand-in manager Roberto Di Matteo and will relish trying to halt Barcelona's bandwagon on Wednesday.
Holders Barcelona were held to a frustrating 0-0 draw at AC Milan in their Champions League quarter-final first leg as the attacking prowess of Lionel Messi and Zlatan Ibrahimovic was all but nullified on Wednesday.
Arsenal clawed back from a two-goal deficit to draw 2-2 with Barcelona on Wednesday in a rip-roaring Champions League quarter-final first leg at the Emirates.
Chelsea survived the dismissal of captain John Terry to eliminate holders Barcelona 3-2 on aggregate and clinch a place in the Champions League final after an action-packed last-four clash on Tuesday in which Lionel Messi missed a penalty.
Chelsea secured top spot, above Barcelona, in Group A with a 2-0 home win over Levski Sofia.
Lionel Messi fired Barcelona into the last 16 of the Champions League with two goals in their 3-0 victory at Spartak Moscow on Tuesday but holders Chelsea are walking a tightrope after a crushing defeat by Juventus.
Holders Barcelona squandered a chance to all but seal a probable King's Cup semi-final showdown with Real Madrid when they conceded a late goal to draw 2-2 at home to 10-man Malaga in their last-eight first-leg match on Wednesday.
A hat-trick by Lionel Messi inspired Barcelona to an 8-0 rout of Osasuna in La Liga on Saturday as the champions responded with a devastating performance after a poor week by their high standards.
Cristiano Ronaldo and Lionel Messi scored twice as Ronaldo's Real Madrid came from behind to beat promoted Hercules 3-1 and Messi's Barcelona humbled 10-man Sevilla 5-0 in La Liga on Saturday.
Barcelona's Lionel Messi set a Champions League scoring record when he took his tally to 14 in the competition so far this season as the holders knocked out AC Milan to reach the semi-finals on Tuesday.
